regAssist Monitor — Parameters

Req ID	Category	Intent	Legal Status	Name	Subdomain(s)	Limit Type	Limit Value	Context	Conditions	Confidence
#P001	chemical	health	guideline	Health-based value (HBV) for malathion	drinking water	requirement	0.29 mg/L	Based on the ADI of 0.03 mg/kg bw per day, a health-based value (HBV) for malathion in drinking water was derived.	Calculated using average body weight of 74 kg, daily volume of tap water consumed of 1.53 L/day, and an allocation factor of 0.20.	high
#P002	chemical	health	guideline	Acceptable daily intake (ADI) for malathion	drinking water	requirement	0.03 mg/kg bw per day	The ADI for malathion is 0.03 mg/kg bw per day. This is calculated by dividing the NOAEL of 3.0 mg/kg bw per day by the uncertainty factor of 100.		high
#P003	chemical	health	guideline	No-observed-adverse-effect level (NOAEL)	drinking water	unknown	3.0 mg/kg bw per day	NOAEL based on chronic progressive nephropathy in female rats was selected as the basis for the current risk assessment.	Based on a treatment-related increase in severity of chronic progressive nephropathy in female rats.	high

Req ID	Name	Context	Confidence
#D001	U.S. EPA	United States Environmental Protection Agency	high
#D002	AHS	Agricultural Health Study	high
#D003	NHL	non-Hodgkin's lymphoma	high
#D004	bw	body weight	high
#D005	LD50	median lethal dose	high
#D006	LC50	inhalation medial lethal concentration	high
#D007	GD	gestational day	high
#D008	PND	postnatal day	high
#D009	UDS	unscheduled DNA synthesis	high
#D010	NOAEL	no-observed-adverse-effect level	high
#D011	ADI	acceptable daily intake	high
#D012	HBV	health-based value	high
#D013	F0	parental rats	high
#D014	F1	first generation - first litter	high
#D015	adenomas	benign liver tumours	high
#D016	resorptions	embryo-fetal loss	high
#D017	PRVD2010-18	proposed re-evaluation decision for the continuing registration of malathion	high

Parameter Viewer